Effects of Antibiotic Consumption on Children 2-8 Years of Age Developing Asthma / 한국역학회지

OBJECTIVES: Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age. METHODS: A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians. RESULTS: Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03). CONCLUSIONS: Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.

Relationship between spiritual well-being, religion, and hope among patients with cancer

Spiritual well-being, religion, and hope are important factors in coping with cancer among patients. Nurses need to understand these concepts within a cultural context. This study aimed to determine the relationship between spiritual well-being, religion, and hope in patients with cancer. In this cross-sectional study, 164 patients with cancer were selected using sequential convenience sampling method. Data were collected using a four-part questionnaire. Descriptive analysis, Pearson correlation and multivariate regression analysis were used to analyses the data. There were significant correlations between the existential well-being, religious well-being, and the hope. There were also significant correlations between the intrinsic religious, religious practices, and the hope. Existential well-being, organizational religiousness and intrinsic religious beliefs predicted hope. The results of this study emphasized on the importance of the spiritual well-being and religion as variables affecting on hope in patients with cancer. This would help nurses and clinical specialists to focus on religion and spirituality well-being in order to increase hope in the patients

Coagulase negative staphylococcus; the most common cause of neonatal septicemia in Urmia, Iran

A prospective study to determine the prevalent bacterial agents of neonatal sepsis and their antimicrobial susceptibility in Imam Khomeini teaching hospital, Urmia, from Oct 2002 to Nov 2006. Newborns with clinical signs of septicemia and positive blood culture during fifty months were prospectively studied. Samples for blood cultures, complete blood count, erythrocyte sedimentation rate, C-reactive protein, sugar, electrolytes, cerebrospinal fluid and urine analysis/culture were obtained; ampicillin and gentamycin were started empirically. Results were analyzed by SPSSis package and cross tabulation was done. Two thousand three hundred twenty five newborns from 4827 neonatal admissions were screened for septicemia. Two hundred twenty seven episodes of sepsis occurred in 209 newborns. The boys/girls ratio was 1.67: 1 and 63.9% of patients were premature. There were 164 [72.2%] cases of EONS and 63 [27.7%] cases of LONS. Coagulase negative Staphylococcus [CONS] was the most common [54%] cause of both early and late onset neonatal sepsis and showed high degree of resistance to commonly used antibiotics; ampicillin [100%], ceftriaxon [65%], cefotaxim [67%] and gentamicin [51%], but comparatively low resistance to vancomycine [10%], imipenem [19%], and ciprofloxacine [23%]. Neonatal sepsis in our ward is mainly caused by gram-positive organisms, which are developing resistance to commonly used antibiotics. The initial empirical choice of ampicillin and gentamycin appears to be unreasonable for our environment